Isn't the philosophical issue something like, we see that the more removed we get from the things that concern our survival as life forms, the less they make intuitive sense? This is true in the macroscopic realm as well when we get to distant galaxies. Gravity isn't enough to hold them together so we have to apply the dark matter bandaid.
It bears on the difference between fundamental reality and our perception of it, if it even makes sense to think about that. What does the world look like if you are a giant pacific octopus, the kind Sy Montgomery wrote about?